Dive et al. argue to limit the scope, scale, and quantity of results in genomic screening programs at the population level. Their analysis offers two interrelated reasons for this recommendation: f...

There has recently been a reappraisal of value in UK construction and calls from a wide range of influential individuals, professional institutions and government bodies for the industry to exceed stakeholders’ expectations and develop integrated teams that can deliver world class products and services. As such value is certainly topical, but the importance of values as a separate but related concept is less well understood. Most construction firms have well-defined and well-articulated values, expressed in annual reports and on websites; however, (...) the lack of rigorous and structured approaches published within construction management research and the practical, unsupported advice on construction institution websites may indicate a shortfall in the approaches used. This article reviews and compares the content and␣structure of some of the most widely used values approaches, and discusses their application within the construction sector. One of the most advanced and empirically tested theories of human values is appraised, and subsequently adopted as a suitable approach to eliciting and defining shared organisational values. Three studies within six construction organisations demonstrate the potential application of this individually grounded approach to reveal and align the relative values priorities of individuals and organisations to understand the strength of their similarity and difference. The results of these case studies show that this new universal values structure can be used along with more qualitative elicitation techniques to understand organisational cultures. (shrink)

William of Malmesbury's Regesta Regum Anglorum is one of the great histories of England, and one of the most important historical works of the European Middle Ages. Although its focus is national, its scope encompasses most of Western Europe and beyond, providing a full-scale account of the First Crusade. Apart from its formidable learning, it is characterized by narrative skill and entertainment value - with topics including unpowered flight and Henry I's zoo. This edition in the Oxford Medieval Texts series (...) is the first modern translation and edition. A full historical introduction is supplied in Volume II. (shrink)

William of Malmesbury's Regesta Regum Anglorum is one of the great histories of England, and one of the most important historical works of the European Middle Ages. Although its focus is national, its scope encompasses most of Western Europe and beyond, providing a full-scale account of the First Crusade. Apart from its formidable learning, it is characterized by narrative skill and entertainment value - with topics including unpowered flight and Henry I's zoo. This edition in the Oxford Medieval Texts series (...) is the first modern translation and edition. A full historical introduction is supplied in Volume II. (shrink)

Lists of species underpin many fields of human endeavour, but there are currently no universally accepted principles for deciding which biological species should be accepted when there are alternative taxonomic treatments (and, by extension, which scientific names should be applied to those species). As improvements in information technology make it easier to communicate, access, and aggregate biodiversity information, there is a need for a framework that helps taxonomists and the users of taxonomy decide which taxa and names should be used (...) by society whilst continuing to encourage taxonomic research that leads to new species discoveries, new knowledge of species relationships, and the refinement of existing species concepts. Here, we present 10 principles that can underpin such a governance framework, namely (i) the species list must be based on science and free from nontaxonomic considerations and interference, (ii) governance of the species list must aim for community support and use, (iii) all decisions about list composition must be transparent, (iv) the governance of validated lists of species is separate from the governance of the names of taxa, (v) governance of lists of accepted species must not constrain academic freedom, (vi) the set of criteria considered sufficient to recognise species boundaries may appropriately vary between different taxonomic groups but should be consistent when possible, (vii) a global list must balance conflicting needs for currency and stability by having archived versions, (viii) contributors need appropriate recognition, (ix) list content should be traceable, and (x) a global listing process needs both to encompass global diversity and to accommodate local knowledge of that diversity. We conclude by outlining issues that must be resolved if such a system of taxonomic list governance and a unified list of accepted scientific names generated are to be universally adopted. (shrink)

Martin Heidegger is, perhaps, the most controversial philosopher of the twentieth-century. Little has been written on him or about his work and its significance for educational thought. This unique collection by a group of international scholars reexamines Heidegger's work and its legacy for educational thought.

Gilbert et al. argue that the neuroethics literature discussing the putative effects of Deep Brain Stimulation on personality largely ignores the scientific evidence and presents distorted claims that personality change is induced by the DBS stimulation. This study contributes to the first-hand primary research on the topic exploring DBS clinicians’ views on post-DBS personality change among their patients and its underlying cause. Semi-structured interviews were conducted with sixteen clinicians from various disciplines working in Australian DBS practice for movement disorders and/or (...) psychiatric conditions. Thematic analysis of the interviews revealed five primary themes: 1) types, frequency and duration of personality change, 2) causes of personality change, 3) impact on patient and family, 4) communication, comprehension and awareness, and 5) management. Clinicians described a variety of personality changes in Parkinson’s disease following DBS including irritability, impulsivity and impaired decision-making. The frequency of personality change seen in patients varied amongst clinicians, but changes were overwhelmingly transient. Clinicians considered both DBS stimulation and additional factors as inducing personality change. For DBS patients with major depressive disorder, a restoration of pre-morbid personality was associated with alleviation of illness. Considerations for future research of personality change following DBS include selecting suitable tools for quantitative examination and developing a common language between the scientific and ethics communities. Clinical implications including recommendations for the informed consent process for patients and families and clinicians’ management of personality change are discussed. (shrink)

Gilbert et al. argue that the neuroethics literature discussing the putative effects of Deep Brain Stimulation on personality largely ignores the scientific evidence and presents distorted claims that personality change is induced by the DBS stimulation. This study contributes to the first-hand primary research on the topic exploring DBS clinicians’ views on post-DBS personality change among their patients and its underlying cause. Semi-structured interviews were conducted with sixteen clinicians from various disciplines working in Australian DBS practice for movement disorders and/or (...) psychiatric conditions. Thematic analysis of the interviews revealed five primary themes: 1) types, frequency and duration of personality change, 2) causes of personality change, 3) impact on patient and family, 4) communication, comprehension and awareness, and 5) management. Clinicians described a variety of personality changes in Parkinson’s disease following DBS including irritability, impulsivity and impaired decision-making. The frequency of personality change seen in patients varied amongst clinicians, but changes were overwhelmingly transient. Clinicians considered both DBS stimulation and additional factors as inducing personality change. For DBS patients with major depressive disorder, a restoration of pre-morbid personality was associated with alleviation of illness. Considerations for future research of personality change following DBS include selecting suitable tools for quantitative examination and developing a common language between the scientific and ethics communities. Clinical implications including recommendations for the informed consent process for patients and families and clinicians’ management of personality change are discussed. (shrink)

Gilbert et al. argue that the neuroethics literature discussing the putative effects of Deep Brain Stimulation on personality largely ignores the scientific evidence and presents distorted claims that personality change is induced by the DBS stimulation. This study contributes to the first-hand primary research on the topic exploring DBS clinicians’ views on post-DBS personality change among their patients and its underlying cause. Semi-structured interviews were conducted with sixteen clinicians from various disciplines working in Australian DBS practice for movement disorders and/or (...) psychiatric conditions. Thematic analysis of the interviews revealed five primary themes: 1) types, frequency and duration of personality change, 2) causes of personality change, 3) impact on patient and family, 4) communication, comprehension and awareness, and 5) management. Clinicians described a variety of personality changes in Parkinson’s disease following DBS including irritability, impulsivity and impaired decision-making. The frequency of personality change seen in patients varied amongst clinicians, but changes were overwhelmingly transient. Clinicians considered both DBS stimulation and additional factors as inducing personality change. For DBS patients with major depressive disorder, a restoration of pre-morbid personality was associated with alleviation of illness. Considerations for future research of personality change following DBS include selecting suitable tools for quantitative examination and developing a common language between the scientific and ethics communities. Clinical implications including recommendations for the informed consent process for patients and families and clinicians’ management of personality change are discussed. (shrink)

This is an edition of one of the crucial texts of Renaissance scepticism, Quod nihil scitur, by the Portuguese scholar Franciso Sanches. The treatise, first published in 1581, is a refutation of Aaristotelian dialectics and scientific theory in the search for a true scientific method. This volume provides a critical edition of the original text, an English translation, a substantial introduction, and comprehensive annotation.

In this essay, we suggest practical ways to shift the framing of crisis standards of care toward disability justice. We elaborate on the vision statement provided in the 2010 Institute of Medicine (National Academy of Medicine) “Summary of Guidance for Establishing Crisis Standards of Care for Use in Disaster Situations,” which emphasizes fairness; equitable processes; community and provider engagement, education, and communication; and the rule of law. We argue that interpreting these elements through disability justice entails a commitment to both (...) distributive and recognitive justice. The disability rights movement's demand “Nothing about us, without us” requires substantive inclusion of disabled people in decision‐making related to their interests, including in crisis planning before, during, and after a pandemic like Covid‐19. (shrink)

κάτοπτρον, which is in all the manuscripts, was emended by Canter to κάτοπτον, and this emendation, or Headlam's κατόπτην, has been received by subsequent editors. Those who read κάτοπτον have been in the habit of taking the word to mean here ‘looking down upon’, and in support of this interpretation they sometimes adduce a scholium in M, κατόψιον. This does seem to prove that the scholar, whose note is copied in our scholium, found κάτοπτον in his text. Presumably he took (...) Σαρωνικο πορθμο κάτοπτον to signify ‘descried from the Saronic gulf’, having very possibly in his mind the phrase in Euripides, Hippolytus 30, where the temple of Cypris is said to be κατόψιον γς τσδε, visible from Troezen. At least we ought not without proof to lay to his account what appears to be the solecism of regarding κάτοπτον as if it meant ‘looking down upon’. Headlam's κατόπτην has at least an active force, but I cannot find that it means ‘one who looks down upon’, if that is the sense desired; it is a ‘spy’ or an ‘inspector’. And, at the end of all discussion, when one asks what in fact is this peak or headland that ‘looks down upon the Saronic crossing’, then commentators take refuge in silence or tend to contradict one another. An emendation that nobody can be sure he understands can hardly be regarded as satisfactory. It may be feared that what has happened is this. In order to get rid of κάτοπτρον, which appeared to them devoid of meaning, editors have introduced into the text a word which does not mean what they want it to mean, and which, if it had that meaning, would still present us with a picture which no man can recognize. (shrink)

But if there aren’t, then ‘they’ are not caused by anything and do not cause anything. That certainly appears to be false, however. John’s absence from our party might have been caused by his having fallen ill, and might cause a commotion. Dick’s not eating his soup might have been caused by his having fallen ill, and might cause a commotion.

In lieu of an abstract, here is a brief excerpt of the content:53. AN INDEX OF HUME'S REFERENCES IN A TREATISE OF HUMAN NATURE The index below of Hume's references in the Treatise te the works of other authors excludes those which are accurate and full in his text (of which there are few) and those which are so general, e.g., to Spinoza's atheism, that no passage is specifiable. Hume mentions other writings, for which this index is compiled, in several (...) different ways. Occasionally he mentions the author's name, the title of his book and gives a reference which is less specific than it could be. These have been identified. Often he mentions an author's name only, e.g., de Retz, and in such cases the fullest possible reference has been given. One of Hume's notable intellectual gifts was his ability to distil several pages of a book into one or two sentences of crisp and accurate synthesis. (This skill is most apparent in his summaries of articles in Bayle' s Dictionary in his "Notes on Philosophy", of which the manuscript is in the Royal Society of Edinburgh Library.) In these instances, page references are impossible and the closest indication one can give is a section or chapter. Some of his references are anonymous, e.g., as an 'elegant writer' says, and so are some quotations. These have been identified with one exception. One anonymous reference (number 24 below) requires explanation because it is both anachronistic and interesting. Hume refers to an observation by "a late eminent philosopher". It is anachronistic because the book to which he refers was published after the Treatise; it is interesting because it provides further evidence of Hutcheson's influence on Hume and the latter' s regard for him. The explanation, for Hutcheson was still alive when Vol.11 of the Treatise appeared in 1739, is that 'late' is here being used in the sense of 'recent' - Hutcheson himself uses the word in the same way in referring to Mandeville when the latter was 54. alive. (An enquiry concerning moral good and evil. Section 1, VI.) Further, the System circulated widely among Hutcheson's friends in Scotland and over so many years that it finally appeared posthumously. That Hume could not cite a published work also accounts for the anonymity of the reference to someone he admired. It is often impossible to determine in which language or in which edition Hume read a particular author. Where there is evidence as to which language he used, the title has been given in that language. There are now so many extant editions of the Treatise that Volume, Part, Chapter and Section references are given, as well as the pagination of Selby-Bigge' s edition, so that readers of other editions may be able to use the index. 1.Vol. 1. Title-page. Tacitus, The Histories, Bk. I. 1. 2.Part 1, Sect. 1, p. 2, n. John Locke, An Essay concerning Human Understanding, Bk. I, Chap. I, 8. 3.Sect. VII, p. 17, n. George Berkeley, A Treatise concerning the Principles of Human Knowledge, Introductixi, Sect. 7, e_t seq. 4.Part II, Sect. II, p. 30, n. Nicolas de Malezieu, Elementa Geometrica. 5.Sect. Ill, p. 35, n. John Locke, Essay, Bk. II, Chap. XIV. 6.Sect. IV, p. 43, n. Antoine Arnauld, La logique ou l'art de penser. Part I, Chap. 5. (In some editions Pierre Nicole is named as co-author. The book is also known as the Port Royal Logic). 7.Sect. IV, p. 46, n. Isaac Barrow, Mathematical Lectures. 8.Part III, Sect. Ill, p. 80, n. Thomas Hobbes, Elements of Philosophy, Part Second, Chap. 9. And Tripos : in Three Discourse. Ill, of Liberty and Necessity. 55. Sect. Ill, p. 80, n. e.g., Samuel Clarke, A Demonstration of the Being and Attributes of God, Props. I-III, et. seq. 10.Sect. Ill, p. 81, n. John Locke, Essay, Bk. IV, Chap. X. 11.Sect. VIII, p. 100 and appendix Vol. Ill, p. 630. Cicero, De Finibus Bonorum et Malorum, Bk. V. 1.2. 12.Sect. XIII, p. 153. Jean Francois Paul de Gondi, Cardinal de Retz, Mémoires, Bk. III. The second 'observation' is from Book... (shrink)

Few figures of the Middle Ages command the attention of so many modern disciplines as Robert Grosseteste (c. 1170-1253). Theology, Philosophy, History, and Science are all areas which his life and thought continue to have significance and to inspire re-interpretation. Accompanied by a series of original commentaries, this new edition of Grosseteste's work, with English translation, draws together the perspectives of modern scientists and medieval specialists. Volume I of a six volume series, Knowing and Speaking presents two of the earliest (...) of Grosseteste's works, the treatises On the Liberal Arts and On the Generation of Sounds. These are accompanied by a significant Middle English treatise on the Seven Liberal Arts whose anonymous fifteenth-century author translated and excerpted passages from Grosseteste's treatises in a re-imagining of their structure and function.0Each work is treated separately within the volume, which is constructed in three parts. On the Liberal Arts sets Grosseteste's thoughts on the arts subjects and emphasises moral concerns about the purpose of learning. On the Generation of Sounds builds on the theories and statements of On the Liberal Arts in connection to the production of sound, elaborating the earlier position, relating the generation of sounds to human vocal and speech production. (shrink)

A crucial challenge for critical disability studies is developing an argument for why disabled people should inhabit our democratic, shared public sphere. The ideological and material separation of citizens into worthy and unworthy based on physiological variations imagined as immutable differences is what I call eugenic world building. It is justified by the idea that social improvement and freedom of choice require eliminating devalued human traits in the interest of reducing human suffering, increasing life quality, and building a more desirable (...) citizenry. In this essay, I outline the logic of inclusive and eugenic world building, define and explain the role of the "normate" in eugenic logic, and provide a critical disability studies reading of the 2005 novel Never Let Me Go by Kazuo Ishiguro and its 2010 film adaptation. I argue that the ways of being in the world we think of as disabilities must be understood as the natural variations, abilities, and limitations inherent in human embodiment. When this happens, disability will be understood not as a problem to be eliminated but, rather, as a valid way of being in the world that must be accommodated through a sustaining and sustainable environment designed to afford access for a wide range of human variations. (shrink)

I cannot forbear adding to these reasonings an observation, which may, perhaps, be found of some importance. In every system of morality, which I have hitherto met with, I have always remark'd, that the author proceeds for some time in the ordinary way of reasoning, and establishes the being of a God, or makes observations concerning human affairs; when of a sudden I am surpriz'd to find, that instead of the usual copulations of propositions, is, and is not, I meet (...) with no proposition that is not connected with an ought, or an ought not. This change is imperceptible; but is, however, of the last consequence. For as this ought, or ought not, expresses some new relation or affirmation, 'tis necessary that it shou'd be observ'd and explain'd; and at the same time that a reason should be given, for what seems altogether inconceivable, how this new relation can be a deduction from others, which are entirely different from it. But as authors do not commonly use this precaution, I shall presume to recommend it to the readers; and am persuaded, that this small attention wou'd subvert all the vulgar systems of morality, and let us see, that the distinction of vice and virtue is not founded merely on the relations of objects, nor is perceiv'd by reason. (shrink)

This paper examines the French erudite scholar Théodore Godefroy's (1580-1649) service to Cardinal Richelieu as a commercial expert. Using manuscripts that reveal his reading, connections and intellectual methods, it shows how Godefroy used his connections in the Parisian lettered circles and a politicized group within the Republic of Letters to gather commercial information, and used the techniques of juridical scholarship to organize his collection. His papers suggest that historians must look beyond a narrow canon of "mercantilist" works to understand seventeenth (...) century debates about the governance of commerce, to a broader context of debates about law, history, and sovereignty. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:73. More Hume autograph marginalia in a first edition of the "Treatise". Two sets of marginalia by Hume in copies of the first edition of A Treatise of Human Nature have been published. One is a copy in the British Library. This has 1 2 been described by Connon and Nidditch and was, no doubt, one, at least, of the copies which Hume kept for himself. The marginalia are (...) so extensive as to suggest that, at the time he made them, he may have been hoping for an opportunity to publish a second edition of the Treatise. The other copy with marginalia, a presentation copy to his kinsman, Henry Home, Lord Karnes, has been described by Wallace Nethery, Librarian of the Hóose Library of Phil3 osophy and by Nidditch. There is a third copy of the Treatise with marginalia in Hume's hand which was a pre4 sentation copy to Pope. The Pope copy is inscribed on the flyleaf of Volume I in Hume's handwriting, "To Alexander* Rope Esq at Twickenham". There are 18 corrections in Volume I and 5 in Volume II. They are as follows, the first word or phrase being the error, the second the correction. The first word is usually scratched out in the text and the correction inserted in the margin but sometimes insertions are simply made within the text. 1st EditionSelby-Bigge 1.12.252.8'the' Our' 1.35.2316.1'of 'or' 1.57.428.18'these* 'those' 1.58.829.6'part' 'parts' 1.111.2860.27'defection' 'dissection' 1.126.569.14'it' deleted 1.154.486.1'worn out' "worn it out' 1.240.7136.9'as' 'when' 1.256.21145.28'evidence' 'testimony' 74. ï. 273. 20155.24'instance' 'instances' 1.280.16159.33'gave it's' 'gave it its' Ï.286.25163.22-23'upon observation' 'upon the observation' 1.287.16164.2'cause' 'case' 1.288.5164.15'results* 'result' 1.293.10167.14'exists' 'exist' 1.343.17196.22'opening I' 'opening it I' 1.402.16231.6'presses' 'press' 1.453.1260.34'what the' 'what is the' 11.108.10 336.24 "affections wheel' 'affections to wheel' II. 120. 4 343.19 'cause' 'causes' 11.228.23404.15 'One' Our' 11.229.19 404.32 'and proceed' 'and practice proceed' 11.271.24428. 20 'considerably' 'sensibly' In addition, someone, perhaps Hume, has marked a printer's error where a letter has slipped. (Vol. I, p. 466. 3). It is not possible to find out the date upon which Hume gave this copy to Pope from the published correspondence of either party. Pope died in 1744 and Hume may have sent him a copy of the Treatise because of the former's literary renown and because the publishers had a large number of unsold copies on their hands. From the fact, among others, that the footnote on Volume II, p. 168 (Selby-Bigge, p. 371) is missing from both the Pope1 and the Karnes copies, it is clear that Volumes I and II were, as one might expect of presentations, in each case early issues or states. It is more than likely that Hume made other presents of the Treatise to friends and people he admired such as Francis Hutcheson and Bishop Butler, and these 75. would probably have included marginalia along the same lines as the Karnes and Pope copies. For what Hume substantially did in giving these copies was to perform an act of courtesy; i.e., to incorporate items from the errata tables into the text. The Pope copy is the least important and interesting of those noticed so far, for it contains only one correction which is not included in the errata tables - the second item listed above in Volume I - and not all of them. The percentage of the changes called for in the errata tables which are made by Hume in the text diminishes markedly as between Volumes I and II. Moreover, there are no marginalia in the third volume, 'Of Morals', and this is perhaps to be explained by Hume's becoming bored with this somewhat superfluous task, even if it was a politeness and the fact... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:73. More Hume autograph marginalia in a first edition of the "Treatise". Two sets of marginalia by Hume in copies of the first edition of A Treatise of Human Nature have been published. One is a copy in the British Library. This has 1 2 been described by Connon and Nidditch and was, no doubt, one, at least, of the copies which Hume kept for himself. The marginalia are (...) so extensive as to suggest that, at the time he made them, he may have been hoping for an opportunity to publish a second edition of the Treatise. The other copy with marginalia, a presentation copy to his kinsman, Henry Home, Lord Karnes, has been described by Wallace Nethery, Librarian of the Hóose Library of Phil3 osophy and by Nidditch. There is a third copy of the Treatise with marginalia in Hume's hand which was a pre4 sentation copy to Pope. The Pope copy is inscribed on the flyleaf of Volume I in Hume's handwriting, "To Alexander* Rope Esq at Twickenham". There are 18 corrections in Volume I and 5 in Volume II. They are as follows, the first word or phrase being the error, the second the correction. The first word is usually scratched out in the text and the correction inserted in the margin but sometimes insertions are simply made within the text. 1st EditionSelby-Bigge 1.12.252.8'the' Our' 1.35.2316.1'of 'or' 1.57.428.18'these* 'those' 1.58.829.6'part' 'parts' 1.111.2860.27'defection' 'dissection' 1.126.569.14'it' deleted 1.154.486.1'worn out' "worn it out' 1.240.7136.9'as' 'when' 1.256.21145.28'evidence' 'testimony' 74. ï. 273. 20155.24'instance' 'instances' 1.280.16159.33'gave it's' 'gave it its' Ï.286.25163.22-23'upon observation' 'upon the observation' 1.287.16164.2'cause' 'case' 1.288.5164.15'results* 'result' 1.293.10167.14'exists' 'exist' 1.343.17196.22'opening I' 'opening it I' 1.402.16231.6'presses' 'press' 1.453.1260.34'what the' 'what is the' 11.108.10 336.24 "affections wheel' 'affections to wheel' II. 120. 4 343.19 'cause' 'causes' 11.228.23404.15 'One' Our' 11.229.19 404.32 'and proceed' 'and practice proceed' 11.271.24428. 20 'considerably' 'sensibly' In addition, someone, perhaps Hume, has marked a printer's error where a letter has slipped. (Vol. I, p. 466. 3). It is not possible to find out the date upon which Hume gave this copy to Pope from the published correspondence of either party. Pope died in 1744 and Hume may have sent him a copy of the Treatise because of the former's literary renown and because the publishers had a large number of unsold copies on their hands. From the fact, among others, that the footnote on Volume II, p. 168 (Selby-Bigge, p. 371) is missing from both the Pope1 and the Karnes copies, it is clear that Volumes I and II were, as one might expect of presentations, in each case early issues or states. It is more than likely that Hume made other presents of the Treatise to friends and people he admired such as Francis Hutcheson and Bishop Butler, and these 75. would probably have included marginalia along the same lines as the Karnes and Pope copies. For what Hume substantially did in giving these copies was to perform an act of courtesy; i.e., to incorporate items from the errata tables into the text. The Pope copy is the least important and interesting of those noticed so far, for it contains only one correction which is not included in the errata tables - the second item listed above in Volume I - and not all of them. The percentage of the changes called for in the errata tables which are made by Hume in the text diminishes markedly as between Volumes I and II. Moreover, there are no marginalia in the third volume, 'Of Morals', and this is perhaps to be explained by Hume's becoming bored with this somewhat superfluous task, even if it was a politeness and the fact... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Ethical, Legal, and Social Implications Research Program at the National Human Genome Research InstituteEric M. Meslin (bio), Elizabeth J. Thomson (bio), and Joy T. Boyer (bio)Organizers of the Human Genome Project (HGP) understood from the beginning that the scientific activities of mapping and sequencing the human genome would raise ethical, legal, and social issues that would require careful attention by scientists, health care professionals, government officials, and (...) the public. The establishment of the ELSI (ethical, legal, and social implications) programs at the National Human Genome Research Institute (NHGRI) and the Department of Energy (DOE) was thought to be vital to the success of the HGP in the United States. It also provided a novel approach to the simultaneous study of ethical, legal, and social issues and basic scientific issues. Eric Juengst, the first director of the ELSI program, described its origins in a previous issue of the Kennedy Institute of Ethics Journal (Juengst 1991). Now in its seventh year, the ELSI program has accomplished much. This article summarizes the evolution and goals of the ELSI program at NHGRI, outlines the program’s current research priorities with examples of activities within each priority area, and provides a look to the future, including the initiation of a strategic planning process.Evolution and Goals of the ELSI Research ProgramThe HGP’s “genomic” goals are unique: to map and sequence the entire human genome—some 3 billion base pairs that make up approximately 80–100,000 genes—and the genomes of related model organisms by the year 2005. This goal was particularly ambitious since, when it was proposed, the technologies for mapping and sequencing had yet to be developed. When the HGP was first established, its organizers also elaborated a set of ELSI goals, which they saw as vital to the success of the genome project. The original ELSI goals were: (1) to anticipate and address the implications of the HGP for individuals and society and (2) to examine the ELSI consequences of mapping and sequencing the human genome in order to stimulate public discussion. To meet these goals, the NHGRI created its ELSI research program in 1990. Along with mapping, sequencing, [End Page 291] and mammalian genetics, ELSI was one of four original branches in the NHGRI Division of Extramural Research that funded research in those areas. Although the individual “branches” no longer exist, the mechanisms for funding research remain much the same. While the overall goals of the program have not changed, the specific ways of achieving the goals have continued to evolve. The importance of the ELSI program lies not in the collection of a full set of data that will be valuable in and of itself, but in the value of using and interpreting this new set of information.Early on, the NHGRI described a set of somewhat more specific goals: (1) to develop a program to help understand the ethical, legal, and social implications of the human genome project and (2) to identify and define the major issues of concern and develop policy options to address them. These more specific goals have been largely met. As the most recent biennial NHGRI Progress Report notes, “a robust ELSI research and education program has been established, many of the most urgent ELSI issues have been identified, and many policy options to address these issues have been proposed” (NCHGR 1995, p. 21). Between 1990 and 1996, ELSI provided more than $32.5 million in funding through 128 research and education grants in more than 30 states and in Canada (Table 1). The ELSI research budget is unique in that when originally created, it was specifically tied to the amount of money provided for the overall NHGRI budget. The NHGRI originally devoted 3 percent of its extramural budget to fund ELSI projects, but in FY 1991, it increased the ELSI budget to 5 percent, a figure that remains today. Table 2 lists the expenditures for each fiscal year since 1990 and the cumulative expenditures to date. The ELSI research budget at NHGRI this year will be about $7 million. When other sources of funding—e.g., co-funding arrangements with other institutes and agencies and the funding of ELSI... (shrink)

I cannot forbear adding to these reasonings an observation, which may, perhaps, be found of some importance. In every system of morality, which I have hitherto met with, I have always remark'd, that the author proceeds for some time in the ordinary way of reasoning, and establishes the being of a God, or makes observations concerning human affairs; when of a sudden I am surpriz'd to find, that instead of the usual copulations of propositions, is , and is not , (...) I meet with no proposition that is not connected with an ought , or an ought not. This change is imperceptible; but is, however, of the last consequence. For as this ought, or ought not, expresses some new relation or affirmation, 'tis necessary that it shou'd be observ'd and explain'd; and at the same time that a reason should be given, for what seems altogether inconceivable, how this new relation can be a deduction from others, which are entirely different from it. But as authors do not commonly use this precaution, I shall presume to recommend it to the readers; and am persuaded, that this small attention wou'd subvert all the vulgar systems of morality, and let us see, that the distinction of vice and virtue is not founded merely on the relations of objects, nor is perceiv'd by reason. (shrink)

James Frederick Ferrier was born in Edinburgh on June 16th, 1808. He was educated privately and at the Royal High School, Edinburgh. After spending two sessions at Edinburgh University, he entered Magdalen College, Oxford, where he graduated in 1831. Returning to Edinburgh, he qualified as an advocate in 1832, but devoted himself to philosophical studies, largely as a result of his close friendship with Sir William Hamilton. In 1838-9, he published An Introduction to the Philosophy of Consciousness in Blackwood's Magazine. (...) This was followed by a number of interesting articles and reviews, chiefly on sense-perception. In 1844, Ferrier deputised for SirWilliam Hamilton in the Chair of Logic and Metaphysics at Edinburgh, and, in the following year, he became Professor of Moral Philosophy and Politica Economy in St Andrews. In 1854, he published The Institutes of Metaphysics. He died in 1864, leaving behind him a valuable course of Lectures on Greek Philosophy, which was published posthumously. (shrink)

This book is another work on the voluminous literature on the Private Language Argument. The author devotes his arguments solely to a refutation of "anti-private language thesis" as it appears in the articles of N. Malcolm, J. D. Carney, and Newton Garver. Two arguments of the thesis are considered without ascription to Wittgenstein’s Philosophical Investigations. The first is the familiar "The Diary Keeper Argument" found in Wittgenstein : "The claim that the supposition that one could keep a record of a (...) particular kind of sensation having no publicly observable behavioral or circumstantial indicators is unintelligible". Smerud’s attack on this argument in part relies on Ayer’s paper "Can There Be a Private Language?" on the issue of recognition. For the issue on the criterion requirement, Smerud appealed to J. J. Thomson’s paper "Private Languages" as a basis for argument. No note is taken of the criticism of the relevance of verification principle to the issue in D. Locke’s Myself and Others. (shrink)

The late eleventh and twelfth centuries were Europe's first age of pamphlet warfare, of invective and satire. The perceived failure, or at least hypocrisy, of its new institutions-the new monastic orders and the reformed papacy-gave rise to the phenomenon, and it was shaped by the study of grammar and rhetoric in the new Schools. The central figures in the texts in the present book are Bernard of Clairvaux, the powerful ostensible founder of the Cistercian order, and the popular and influential (...) teacher Peter Abelard, leader of the radical faction in the Schools of Paris. The event which sparked this controversy was the Church council at Sens in 1141 which had led to the condemnation of Abelard's doctrines. Abelard proposed to use reason to explain the mysteries of faith, and this had led him into all kinds of difficulties with established church doctrine. The leading light in the atttack on his ideas was Bernard, the famous abbot of Clairvaux, a group of whose letters, written to gather support for it before and after the Council, are presented here. A little while later Abelard was defended by the vituperative but otherwise unknown Berengar, who wrote an outrageous Apology attacking Bernard; we also edit his remaining polemical works: his Letter to the Carthusians, and his Letter to the Bishop of Mende. None of Berengar's works has been translated before. An extensive introductory essay describes the course of the debate and the personnel, and analyses the invective employed by both Bernard and Berengar. There is full annotation identifying the writers' sources and clarifying the issues."-- Back cover. (shrink)

Accompanying _The_ _Routledge Doctoral Student’s Companion_ this book examines what it means to be a doctoral student in education and the social sciences, providing a guide for those supervising students. Exploring the key role and pedagogical challenges that face supervisors in students’ personal development, the contributors outline the research capabilities which are essential for confidence, quality and success in doctorate level research. Providing guidance about helpful resources and methodological support, the chapters: frame important questions within the history of debates act (...) as a road map through international literatures make suggestions for good practice raise important questions and provide answers to key pedagogical issues provide advice on enabling students’ scholarly careers and identities. While there is no one solution to ideal supervision, this wide-ranging text offers resources that will help supervisors develop their own personal approach to supervision. Ideal for all supervisors whether assisting part-time of full-time students, it is also highly suitable for helping academics to support international students who confront Western doctoral traditions and academic cultures, helping both supervisor and student to understand why things are as they are. (shrink)

One of the most recent and original adaptations of Mary Wollstonecraft (Godwin) Shelley's Frankenstein; or, The Modern Prometheus (1818) is the ballet version choreographed by Liam Scarlett and performed by the Royal Ballet in 2016 and the San Francisco Ballet in 2017 and 2018. What emerges from this translation is an economical, emotionally wrenching, and visually elegant drama of family tragedy from which we can draw a cautionary tale about contemporary bioethical dilemmas in family making that new and forthcoming biomedical (...) technologies present. This performance of bodies interacting suggests the need for an ethics of acceptance and recognition as people navigate complex familial relationships involving procreative liberty, questions of moral personhood, and parental obligation. In the Frankenstein ballet, the narrative genre of dance—what I'll call “story in the flesh”—invites viewers to identify with the characters and enter into the complexity of interpersonal relations. The ballet becomes a compelling testimony about possible unintended outcomes set in motion by well‐intended fallible humans like themselves. (shrink)

How should we live? What do we owe to other people? In Goodness and Advice, the eminent philosopher Judith Jarvis Thomson explores how we should go about answering such fundamental questions. In doing so, she makes major advances in moral philosophy, pointing to some deep problems for influential moral theories and describing the structure of a new and much more promising theory. Thomson begins by lamenting the prevalence of the idea that there is an unbridgeable gap between fact (...) and value--that to say something is good, for example, is not to state a fact, but to do something more like expressing an attitude or feeling. She sets out to challenge this view, first by assessing the apparently powerful claims of Consequentialism. Thomson makes the striking argument that this familiar theory must ultimately fail because its basic requirement--that people should act to bring about the "most good"--is meaningless. It rests on an incoherent conception of goodness, and supplies, not mistaken advice, but no advice at all. Thomson then outlines the theory that she thinks we should opt for instead. This theory says that no acts are, simply, good: an act can at most be good in one or another way--as, for example, good for Smith or for Jones. What we ought to do is, most importantly, to avoid injustice; and whether an act is unjust is a function both of the rights of those affected, including the agent, and of how good or bad the act is for them. The book, which originated in the Tanner lectures that Thomson delivered at Princeton University's Center for Human Values in 1999, includes two chapters by Thomson ("Goodness" and "Advice"), provocative comments by four prominent scholars--Martha Nussbaum, Jerome Schneewind, Philip Fisher, and Barbara Herrnstein Smith--and replies by Thomson to those comments. (shrink)

In Heidegger on Ontotheology: Technology and the Politics of Education, I argue that Heidegger’s ontological thinking about education forms one of the deep thematic undercurrents of his entire career, but I focus mainly on Heidegger’s later work in order to make this case. The current essay extends this view to Heidegger’s early magnum opus, contending that Being and Time is profoundly informed – albeit at a subterranean level – by Heidegger’s perfectionist thinking about education. Explaining this perfectionism in terms of (...) its ontological and ethical components (and their linkage), I show that Being and Time’s educational philosophy seeks to answer the paradoxical question: How do become what we are? Understanding Heidegger’s strange but powerful answer to this original pedagogical question, I suggest, allows us to make sense of some of the most difficult and important issues at the heart of Being and Time, including what Heidegger really means by possibility, death, and authenticity. (shrink)

The purpose of the study was to compare the visuospatial decision-making error scores related to the perception of biological motion of individuals categorized as field dependent or field independent. A sample of 69 participants aged 18-27 years that included 33 males and 36 females completed the experiment. Cognitive style was assessed using the Group Embedded Figure Test. Perception of biological motion was evaluated using two different point-light stimuli developed from video images of a ballet dancer’s performance of a correct and (...) incorrect turn in the fifth position. The results showed that individuals classified as field independent made significantly fewer visuospatial processing errors. The findings are considered and discussed in relation to theoretical perspectives associated with both cognitive processing and cognitive style. (shrink)

Heidegger's Destruktion of the metaphysical tradition leads him to the view that all Western metaphysical systems make foundational claims best understood as 'ontotheological'. Metaphysics establishes the conceptual parameters of intelligibility by ontologically grounding and theologically legitimating our changing historical sense of what is. By first elucidating and then problematizing Heidegger's claim that all Western metaphysics shares this ontotheological structure, I reconstruct the most important components of the original and provocative account of the history of metaphysics that Heidegger gives in support (...) of his idiosyncratic understanding of metaphysics. Arguing that this historical narrative generates the critical force of Heidegger's larger philosophical project (namely, his attempt to find a path beyond our own nihilistic Nietzschean age), I conclude by briefly showing how Heidegger's return to the inception of Western metaphysics allows him to uncover two important aspects of Being's pre-metaphysical phenomenological self-manifestation, aspects which have long been buried beneath the metaphysical tradition but which are crucial to Heidegger's attempt to move beyond our late-modern, Nietzschean impasse. (shrink)

Child safety is everybody's concern, but much professional activity is misinformed or based on a misrepresentation of the facts, and preventative action is rarely adequately evaluated. Written and edited by leading researchers with an active role in social policy, this new book challenges both our understanding of the problem of child safety and points to the impotence of "educational" approaches based on "knowledge enhancement". The strong message is that improving children's knowledge has little or no effect on their behaviour. From (...) the physical abuse of young children to drug abuse in adolescence, this book presents a radical new perspective on a key social issue. (shrink)

This essay explores the undervalued methodological elements underpinning Kant’s Transition from Metaphysical Foundations of Natural Science to Physics in Opus postumum. I do this by drawing...

La modernité, dès ses débuts, attribue un rôle-clef aux passions : qu’elles soient hostiles à la Raison ou au contraire ses alliées, dangereuses ou fascinantes, elles marquent le rôle du corps, du désir, du langage et de l’imagination dans la nature de l’homme. La même époque voit se développer différentes variantes du matérialisme. Presque toutes réévaluent ce que la raison classique avait tendance à réprimer ou à considérer comme révélateur de la faiblesse humaine : le corps et tout ce qui, (...) dans l’âme ou dans la société, porte les traces de l’activité et de la positivité du corps. On peut donc s’attendre à ce que les matérialistes fassent un sort particulier aux passions, à ce qu’ils y reconnaissent des lois et non pas seulement des manques ou des vices, à ce qu’ils essaient d’en repérer l’efficace dans l’ensemble des activités humaines. Encore faut-il se demander comment chaque matérialisme procède, par quelle configuration propre il rend compte de ces phénomènes ou comment il dévie les discours de la théorie classique pour les forcer à passer par les objets qui sont les siens. Plutôt que de supposer l’existence d’une théorie matérialiste unique, une enquête s’impose donc qui prenne en vue la diversité de ces auteurs, les situe dans leur contexte et repère les points d’inflexion que rencontre chez chacun d’entre eux cette problématique générale des passions qui semble avoir gouverné plusieurs siècles. (shrink)

But what if in order to save 0nc’s life one has to ki]1 another person? In some cases that is obviously permissible. In a case I will call Villainous Aggrcssor, you are standing in :1 meadow, innocently minding your own business, and 21 truck suddenly heads toward you. You try to sidestep the truck, but it tums as you tum. Now you can sec the driver: he is a mam you know has long hated you. What to do? You cannot (...) outrun thc truck. Fortunately, this is not pure nightmare: you just happen to have em antitank gun with you, and can blow up the truck. Of course, if you do this you will kill thc driver, but that does not matter; it is morally permissible for you to blow up thc truck, driver and 211, in defense of your life. (shrink)